BCG (Bacille Calmette-Guérin) HspCs (heat-shock protein-peptide complexes) induce T-helper 1 responses and protect against live challenge in a murine aerosol challenge model of pulmonary tuberculosis.

نویسندگان

  • C A L S Colaco
  • C R Bailey
  • J Keeble
  • K B Walker
چکیده

The need for an effective TB (tuberculosis) vaccine remains acute, with tuberculosis still one of the major killers worldwide and 3 million new infections annually. We report here on the immune responses elicited by HspCs (heat-shock protein-peptide complexes) isolated from BCG (Bacille Calmette-Guérin) vaccine. These HspCs elicit both the appropriate cellular and protective immune responses required to merit their further development as TB vaccine candidates.

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عنوان ژورنال:
  • Biochemical Society transactions

دوره 32 Pt 4  شماره 

صفحات  -

تاریخ انتشار 2004